Publications
34.
G. Lenardon, X. Yzeiri, G. Le Berre, D. B. Yildiz, D. Leonori*, A. Ruffoni*
“A photochemical strategy for aromatic nitrogen ortho-isomerization“
Chem. Sci., 2025, 16, 21416 – 21422
- https://www.peeref.com/works/87477502
- 2025 Chemical Science HOT Article Collection https://pubs.rsc.org/en/journals/articlecollectionlanding?sercode=sc&themeid=a131bcbd-b300-4c1e-baf6-f1f83f4fb0f8
33.
M. Alonso, G. Lonardi, E. M. Arpa, B. Roure, A. Ruffoni*, D. Leonori*
“Photochemical permutation of meta-substituted phenols.”
Nat. Commun. 2025, 16, 7502
32.
W. J. Oliver, P. Blyszczyk, E. M. Arpa, K. Hitoshio, M. Gomez-Mendoza, V. de la Peña O’Shea, I. Marchand, T. Poisson, A. Ruffoni*, D. Leonori*
“Excited-state configuration of nitroarenes enables oxidative cleavage of aromatics over alkenes.”
Science, 2025, 387, 1167-1174.
31.
R. Güdük, N. Kehl, C. Stavagna, M. J. Tilby, O. Turner, A. Ruffoni*, H. P. Caldora*, D. Leonori*
“A Three-step Strategy for the Conversion of Pyridines into Benzonitriles.”
Nat. Synth., 2025, 4, 848–858
30.
T. dos Santos, C. S. Buettner, D. Berna Yildiz, M. Mamone, A. Ruffoni, D. Leonori*.
“Photochemical conversion of indazoles into benzimidazoles.”
Angew. Chem. Int. Ed., 2025, 64, e202423804
29.
J. Corpas, E. Rivera-Chao, E. M. Arpa, M. Gomez-Mendoza, Y. Katayama, V. A. de la Peña O’Shea, C. Bouchel, C. Jacob, P.-G. Echeverria, A. Ruffoni, D. Leonori*.
“Excited-state protonation and reduction enables the umpolung Birch reduction of naphthalenes.”
Chem, 2025, 11, 1-12.
28.
B. Roure, M. Alonso, G. Lonardi, D. Berna Yildiz, C. S. Buettner, T. dos Santos, Y. Xu, M. Bossart, V. Derdau, M. Méndez, J. Llaveria, A. Ruffoni*, D. Leonori*
“Photochemical permutation of thiazoles, isothiazoles and other azoles.“
Nature, 2024, 637, 860 – 867.
27.
J. Corpas, H. Caldora, E. M. Di Tommaso, A. Hernandez, O. Turner, L. M. Azofra, A. Ruffoni*, D. Leonori*.
“A general synthesis of electron rich and electron poor aminated heteroaromatics by desaturative catalysis.”
Nat. Catal., 2024, 7, 593-603
26.
R. Sanchez B., L. Bui, V. K. Duong, A. Ruffoni*, D. Leonori*.
“A photochemical strategy for the synthesis of caprolactams via dearomative ring-expansion of nitroarenes.”
Synthesis, 2024, 56, A-G.
25.
R. Mykura, R. Samchez, E. Matador, V. Duong, A. Varela, L. Angelini, R. J. Carbajo, A. Ruffoni*, D. Leonori*.
“Synthesis of poly-substituted azepanes by dearomative ring-expansion of nitroarenes.”
Nat. Chem., 2024, 16, 771-779.
24.
B. Li, A. Ruffoni*, D. Leonori*.
“A photochemical strategy for ortho-aminophenol synthesis via dearomative-rearomative coupling between aryl azides and alcohols.”
Angew. Chem. Int. Ed., 2023, 62, 1-6.
23.
R. Sanchez, B. Roure, J. Llaveria, A. Ruffoni*, D. Leonori*.
“A photochemical strategy for ortho-phenylenediamines synthesis via dearomatization–rearomatization coupling between nitrobenzenes and amines.”
Chem, 2023, 9, 3685-3695.
22.
E. Matador, M. Tilby, I. Saridakis, M. Pedrón, D. Tomczak, J. Llaveria, I. Atodiresei, P. Merino*, A. Ruffoni*, D. Leonori*.
“A photochemical strategy for the conversion of nitroarenes into rigidified pyrrolidine analogues.“
J. Am. Chem. Soc., 2023, 145, 50, 27810-27820.
21.
S. Basu, P. Martinez-Cristobal, M. Pesarrodona, M. Frigolé-Vivas, M. Lewis, E. Szulc, C. A. Bañuelos, C. Sánchez-Zarzalejo, S. Bielskutė, J. Zhu, K. Pombo-García, C. Garcia-Cabau, C. Batlle, B. Mateos, M. Biesaga, A. Escobedo, L. Bardia, X. Verdaguer, A. Ruffoni, N. R. Mawji, J. Wang, T. Tam, I. Brun-Heath, S. Ventura, D. Meierhofer, J. García, P. Robustelli, T. H. Stracker, M. D. Sadar*, A. Riera*, D. Hnisz*, X. Salvatella*.
“Rational optimization of a transcription factor activation domain inhibitor.”
Nature Structural & Molecular Biology, 2023, 30, 1958-1969.
20.
M. P. Adorni*, M. Galetti, S. La Monica, M. Incerti, A. Ruffoni, L. Elviri, I. Zanotti, B. Papotti, D. Cavallo, R. Alfieri, P. G. Petronini, F. Bernini*.
“A New ABCB1 inhibitor enhances the anticancer effect of doxorubicin in both in vitro and in vivo Models of NSCLC.”
Int. J. Mol. Sci., 2023, 24, 989–1004.
19.
A. Ruffoni, C. Hampton, M. Simonetti*, D. Leonori*.
“Photoexcited nitroarenes for the oxidative cleavage of alkenes.“
Nature, 2022, 7930, 81-86.
18.
A. Ruffoni, R. C. Mykura, M. Bietti, D. Leonori*
“The interplay of polar effects in controlling the selectivity of radical reaction.“
Nat. Synth., 2022, 1, 682-695.
17.
A. J. McMillan, M. Sienkowska, P. Di Lorenzo, G. K. Gransbury, N. F. Chilton, M. Salamone, A. Ruffoni*, M. Bietti*, D. Leonori*.
“Practical and selective sp3 C-H bond chlorination via aminium radicals.“
Angew. Chem. Int. Ed., 2021, 60, 7132– 7139.
16.
S. Govearts, L. Angelini, C. Hampton, L. Malet-Sanz, A. Ruffoni*, D. Leonori*.
“Photoinduced olefin diamination with alkylamine.“
Angew. Chem. Int. Ed., 2020, 59, 15021-15028.
15.
K. J. Hye, A. Ruffoni, Y. S. S. Al-Faiyz, N. S. Sheikh*, D. Leonori*.
“Divergent strain-release amino-functionalization of [1.1.1]propellane with electrophilic nitrogen-radicals.“
Angew. Chem. Int. Ed., 2020, 59, 8225– 8231.
14.
F. Julia, A. Ruffoni, D. Leonori*.
“Aromatic C-H amination using alkyl amine.”
Trends in Chemistry, 2020, 2, 480– 481.
13.
S. Locarno, S. Argentiere, A. Ruffoni, D. Maggioni, R. Soave, R. Bucci, E. Erba, C. Lenardi, M. L. Gelmi, F. Clerici*.
“Self-assembled hydrophobic Ala-Aib peptide encapsulating curcumin: a convenient system for water insoluble drugs.”
RSC Adv., 2020, 10, 9964.
12.
A. Ruffoni, F. Julia, T. D. Svejstrup, A. J. McMillan, J. J. Douglas, D. Leonori*.
“Practical and regioselective amination of arenes using alkyl amines.”
Nat. Chem., 2019, 11, 426– 433.
11.
A. Ruffoni*, N. Ferri, A. Pinto, S. Pellegrino, A. Contini, F. Clerici*.
“Identification of the first enantiopure Rac1-Tiam1 protein-protein interaction inhibitor and its synthesis via phosphine free remote group directed hydroarylation.“
MedChemComm, 2019, 10, 310-314.
10.
D. C. Marcote, R. Street-Jeakings, E. Dauncey, J. J. Douglas, A. Ruffoni*, D. Leonori*.
“Photoinduced decarboxylative azidation of cyclic amino acids.”
Org. Biomol. Chem., 2019, 17, 1839– 1842.
9.
T. D. Svejstrup , A. Ruffoni, F. Julia, A. Valentin, D. Leonori*.
“Synthesis of arylamines via aminium radical.”
Angew. Chem. Int. Ed., 2017, 56, 14948–14952.
8.
D. R. Fernandez, A. Ruffoni, Y. S. S. Al-Faiyz, J. J. Douglas, N. S. Sheikh*, D. Leonori*.
“Visible-light-mediated reaction of electrophilic radicals with vinyl and allyl trifluoroborates.”
ACS Catal., 2017, 7, 4126– 4130.
7.
A. Ruffoni*, A. Contini, R. Soave, L. lo Presti. I. Esposto, I. Maffucci, D. Nava, S. Pellegrino, M. L. Gelmi, F. Clerici*.
“Aqueous self-assembly of short hydrophobic peptides containg norbornene amino acid into supramolecular structures with spherical shape.”
RSC Adv., 2016, 6, 90754-90759.
6.
A. Ruffoni*, A. Contini, R. Soave, L. lo Presti. I. Esposto, I. Maffucci, D. Nava, S. Pellegrino, M. L. Gelmi, F. Clerici*.
“Model peptides containing the 3-sulfanil-norbornene amino acid, a conformationally constrained cysteine analogue effective inducer of 310 -helix secondary structures.”
RSC Adv., 2015, 5 32643-32656.
5.
A. Ruffoni, N. Ferri, S. K. Bernini, C. Ricci, A. Corsini, I. Maffucci, F. Clerici, A. Contini *.
“2-Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: an appealing scaffold for the design of Rac1−Tiam1 protein−protein interaction inhibitors.”
J. Med. Chem., 2014, 57, 2953−2962.
4.
Q. Zhou, A. Ruffoni, R. Gianatassio, Y. Fujiwara, E. Sella, D. Shabat, P. S. Baran*.
“Direct synthesis of fluorinated heteroarylether bioisosteres.”
Org. Biomol. Chem., 2019, 17, 1839– 1842.
3.
A. Casoni, E.Borsini, A.Contini, A.Ruffoni, S.Pellegrino, F.Clerici*.
“Sulfanyl-methylene-5(4H)-oxazolones and β-sulfanyl-α-nitroacrylates as appealing dienophiles for the synthesis of conformationally constrained cysteine analogues.”
Current Organic Chemistry, 2012, 16, 2724-2738.
2.
A. Casoni, E.Borsini, A.Contini, A.Ruffoni, S.Pellegrino, F.Clerici*.
“Hydroarylation of substituted norbornene aminoacids: studies on long-range stereo-electronic effects on the Regioselectivity of the Addition.”
Current Organic Chemistry, 2012, 16, 2724-2738.
1.
A. Casoni, E.Borsini, A.Contini, A.Ruffoni, S.Pellegrino, F.Clerici*.
“A new series of organocatalysts for Diels-Alder cycloaddition reaction and theoretical analysis.”
Current Organic Chemistry, 2011, 15, 3514-3522.
Book Chapter
A. Ruffoni, D. Leonori*.
“Hydroxyphenyl-ethynyl-phenol derivatives as AR (androgen receptor) transcriptional activity modulators for use in the treatment of I.A. prostate cancer.”
WO/2023/061723; PCT/EP2022/076442; 22.09.2022 – 20.04.2023.Jan 26, 2025
Patent
X. Salvatella, A. Riera, M. Frigole-Vivas, C. Sanchez-Zarzalejo, A. Ruffoni, X. Verdaguer, M. D. Sadar, C. A. Banuelos, C. N. Mawji.
“Hydroxyphenyl-ethynyl-phenol derivatives as AR (androgen receptor) transcriptional activity modulators for use in the treatment of I.A. prostate cancer.”
WO/2023/061723; PCT/EP2022/076442; 22.09.2022 – 20.04.2023.Jan 26, 2025
